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“And God said, Behold, I have given you every herb bearing seed, which is upon the face of all the earth, and every tree, in the which is the fruit of a tree yielding seed; to you it shall be for meat”
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This ATLAS presents in appended form the complete monographic study on the subject. The idea is to bring the results out of the "heavier" didactic format required for the scientific presentation and at the same time to systematize all the information needed for the subsequent clinical research.
The present excerpt from monographic work seeks to introduce the possibility that oncological diseases become chronic (like diabetes). The theoretical basis on which we refer is the fact that cancer cells feed only on carbohydrates. In turn, there is evidence that some nitrile glycosides have anti-cancer properties.
The study is divided into four parts presented in the form of goals.
Proceeding from the particular to the general, the fine molecular structure and all possible biochemical reactions of Amygdalin are examined. By itself, it is highly toxic to the physiologically active animal cell. Amygdalin has NO pronounced antitumor properties. In the first goal, he examines precisely the acceptable form for admission. It is concluded that the active anticancer molecular form is a stoichiometric mixture of the amide and carboxyl derivative of the nitrile glycoside.
The second goal is to study the exact action of the anti-tumor product already introduced. After an extremely precise biochemical and mathematical analysis, a series of biochemical cycles of the exact passage of the product through the digestive system, penetration into the blood, approach to cancer cells and selective passage through their cell membrane have been deduced.
The third goal is to define the chemical and pharmaceutical molecular forms. 54 methodological and/or pharmaceutical models with hundreds of variables for each are reviewed and analyzed here.
The fourth goal (it is this purpose that is separately brought out in this edition) presents the interpretable prediction of anticancer susceptibility of glycosidic amides. The affinities of the pharmaceutical form to each known cancer cell line are reviewed. The results surpass many times all anti-cancer drugs and with significantly reduced toxicity.
In an additional part, a generalized clinical control is presented. When conducting the treatment, it is also vitally important to not divert the therapy process to irreversible pathology.
Result: The cancer can become chronic and become a practically curable disease.
Tsanov, V., Tsanov, H. (2024) A T L A S - Interpretable prognosis for susceptibility to active anti-cancer molecular forms, based on amides/carboxylic acids - hydrolysis derivatives of natural nitrile glycosides, of transcriptome cell lines inherent in tumors, Zenodo
ISBN: 978-619-91534-5-1
DOI: 10.5281/zenodo.13777292
HTML 5 version / 31MB single file size /
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The current database represents the exact results of Interpretable prediction for anticancer sensitivity of glycoside amides. It is presented in *.xlsx format. The file includes: analytical data; theoretical basis; conclusions; full filtered data and full raw data. All information is presented in a user-friendly form and fully compatible for any type of data export.
Tsanov, V., Tsanov, H. (2024) Interpretable prediction for anticancer sensitivity of glycoside amides (Version 2) [Data set]
DOI: 10.5281/zenodo.13777312
This ATLAS presents in appended form the complete monographic study on the subject. The idea is to bring the results out of the "heavier" didactic format required for the scientific presentation and at the same time to systematize all the information needed for the subsequent clinical research.
The present excerpt from monographic work seeks to introduce the possibility that oncological diseases become chronic (like diabetes). The theoretical basis on which we refer is the fact that cancer cells feed only on carbohydrates. In turn, there is evidence that some nitrile glycosides have anti-cancer properties.
Tsanov, V., Tsanov, H. (2023) A T L A S - Interpretable prognosis for susceptibility to active anti-cancer molecular forms, based on amides/carboxylic acids - hydrolysis derivatives of natural nitrile glycosides, of transcriptome cell lines inherent in tumors, Zenodo
ISBN: 978-619-91534-5-1
DOI: 10.5281/zenodo.8009390
The current database represents the exact results of Interpretable prediction for anticancer sensitivity of glycoside amides. It is presented in *.xlsx format. The file includes: analytical data; theoretical basis; conclusions; full filtered data and full raw data. All information is presented in a user-friendly form and fully compatible for any type of data export.
Tsanov, V., Tsanov, H. (2023) Interpretable prediction for anticancer sensitivity of glycoside amides (Version 1) [Data set]
DOI: 10.5281/zenodo.7550371
Tsanov, V., Tsanov, H. (2023) Theoretical study of anticancer activity of glycoside amides
[ third supplemented edition ] (Version 3, p. 857)
ISBN: 978-619-91534-4-4
DOI: 10.5281/zenodo.7295357
Tsanov, V., Tsanov, H. (2022) Theoretical study of anticancer activity of glycoside amides
[ second supplemented edition ] (Version 2, p. 453)
ISBN: 978-619-91534-3-7
DOI: 10.5281/zenodo.6467141
Keywords: anticancer cellular effects, glycoside amides, druglikeness, active carboxyl transfer, nitrile glycosides, theoretical analysisBackground: This article is a continuation of Theoretical Analysis for the Safe Form and Dosage of Amygdalin Product and Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell. They consider some possible natural modifications and hypothesize that it is not nitrile glycosides that have antitumor properties but their amide / carboxyl derivatives. The possibility of using this circumstance in conservative oncology is also considered. A mechanism for crossing the cell membrane and overcoming the immune functions of the cancer cell is presented.
The physiologically active cancer cell itself is quite inert to external influences. It is far more stable than any physiologically active structural and/or functional organismal cell. Its defenses are discussed in detail in the article, and its main weakness was defined, namely: the cancer cell feeds mainly on carbohydrates and/ or carbohydrate complexes. In an effort to preserve its gene set, it has evolved to counteract biologically active substances by maximally preventing its passage through its cell membrane.
It is this property that could be used to minimize its effect on the whole body. In the same article, based on theoretical calculations and literature references, a hypothesis is stated: cancers could turn from severe infectious to controlled chronic ones (similar to diabetes, chronic hepatitis, etc.)
Objective: The pharmaceutical form allows deviation from the chemically pure substance. It is a convenient and at the same time accessible (from a financial and/or technological point of view) form for admission by patients.
Due to the great variety of natural glycosamide nitriles (starting material for the production of amide/ carboxylic acid), modern pharmacology allows their combined intake by chemical nature and concentration of the active form crossing the cell membrane.
Natural nitrile glycosides hydrolyzed to amide/carboxylic acid are still unexplored but with great theoretical potential. As biologically active substances, these compounds also have significant toxicity. One of the purposes of this article is to organize laboratory tests on animals.
Methods: A comparative analysis is performed on the basis of stoichiometric calculations for the concentration of the active form and the prediction of the bioactivity. For this purpose, the following methodology is applied: Data analysis for active anticancer cell molecular form and Determination of the drug dose. The derived chemicals obtained immediately after the passage of glycosamide across the cancer cell membrane are: (R)-2-hydroxy-2-phenylacetamide, (R)-2- hydroxy-2-(4-hydroxyphenyl)acetamide, (R)-2-hydroxy-2-(3-hydroxyphenyl)acetamide, 2-hydroxy-2-methylpropanamide, (S)-2-hydroxy-2-methylbutanamide, 2-hydroxy-3-methylbut-2-enamide, (2Z,4E)-4-(2-amino-1-hydroxy-2-oxoethylide ne)hex-2-enedioic acid, (S)-1-hydroxycyclopent-2-ene-1-carboxamide, (1S,4S)-1,4-dihydroxycyclopent-2-ene-1-carbox amide, (1R,4R)-1,4,5-trihydroxycyclopent-2-ene-1-carboxamide, (Z)-2-((4S,6R)-4,6-dihydroxycyclohex-2-en-1-ylidene) acetamide, (R)-2-hydroxy-3-methylbutanamide, (E)-2-((4S,5R,6R)-4,5,6-trihydroxycyclohex-2-en-1-ylidene)acetamide, (Z)-2-((4R,5R,6S)-5,6-dihydroxy-4-methoxycyclohex-2-en-1-ylidene)acetamide, (E)-2-((4R,6S)-4,6-dihydroxycyclohex- 2-en-1-ylidene)acetamide and (E)-2-((4S,5R,6R)-4,5,6-trihydroxycyclohex-2-en-1-ylidene)acetamide.
Results: The use of two or more pharmaceutical forms would not prevent their penetration, subject to the mass ratios between the active antitumor amide and the active carboxyl transfer form.
Conclusion: Amides resulting from the hydrolysis of nitrile glycosides would have the ability to cross the cell membrane of a cancer cell and thus cause its cellular response. The pharmaceutical form must represent the exact amide / carboxylic acid ratio for the corresponding active anticancer cell form.
Tsanov, V., Tsanov, H. (2022) Theoretical Analysis of Anticancer Cellular Effects of Glycoside Amides, Anti-Cancer Agents in Medicinal Chemistry 2022; 22 (6), pp. 1171÷1200, Bentham Science Publisher
print ISSN: 1871-5206 | on-line ISSN: 1875-5992
DOI: 10.2174/1871520621666210903122831
HTML 5 version / 7MB single file size /
alternative link
This book is a long-term study and analysis presented in a more scientifically popular form. The matter is presented in a freer way in order to explain the matter.
The present monographic work seeks to introduce the possibility that oncological diseases become chronic (like diabetes). The theoretical basis on which we refer is the fact that cancer cells feed only on carbohydrates. In turn, there is evidence that some nitrile glycosides have anti-cancer properties.
The study is divided into four parts presented in the form of goals.
Proceeding from the particular to the general, the fine molecular structure and all possible biochemical reactions of Amygdalin are examined. By itself, it is highly toxic to the physiologically active animal cell. Amygdalin has NO pronounced antitumor properties. In the first goal, he examines precisely the acceptable form for admission. It is concluded that the active anticancer molecular form is a stoichiometric mixture of the amide and carboxyl derivative of the nitrile glycoside.
The second goal is to study the exact action of the anti-tumor product already introduced. After an extremely precise biochemical and mathematical analysis, a series of biochemical cycles of the exact passage of the product through the digestive system, penetration into the blood, approach to cancer cells and selective passage through their cell membrane have been deduced.
The third goal is to define the chemical and pharmaceutical molecular forms. 54 methodological and/or pharmaceutical models with hundreds of variables for each are reviewed and analyzed here.
The fourth goal presents the interpretable prediction of anticancer susceptibility of glycosidic amides. The affinities of the pharmaceutical form to each known cancer cell line are reviewed. The results surpass many times all anti-cancer drugs and with significantly reduced toxicity.
In an additional part, a generalized clinical control is presented. When conducting the treatment, it is also vitally important to divert the therapy process to irreversible pathology.
Result: The cancer can become chronic and become a practically curable disease.
Tsanov, V., Tsanov, H. (2021) Theoretical study of anticancer activity of glycoside amides, (p. 402)
ISBN: 978-619-91534-1-3
DOI: 10.5281/zenodo.5665079
Keywords: glycoside amides, cancer cell membrane, hydrolysis, PM7, TD-DFT, apoptosisBackground: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semiempirical methods, are considered.
Objective: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and/or modified forms to counteract "external" bioactive activity. For their part, cancers have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops accordingly.
Methods: Pedestal is derived that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent densityfunctional quantum-chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to bioactive forms causing chemical apoptosis of the cell-independent of its non-genetic set, which seeks to counteract the process.
Results: Used in oncology, it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime).
Conclusion: The amide derivatives of nitrile glycosides exhibit anticancer activity; the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide-carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and/or permanently damage its normal physiology.
Tsanov, V., Tsanov, H. (2020) Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell, Anti-Cancer Agents in Medicinal Chemistry 2021; 21 (12), pp. 1612÷1623, Bentham Science Publisher
print ISSN: 1871-5206 | on-line ISSN: 1875-5992
DOI: 10.2174/1871520620999201103201008
HTML 5 version / 7MB single file size /
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Indroduction: This article presents a theoretical analysis of the safe form and dosage of the amygdalin derivative. By making a precise socio-anthropological analysis of the life of the ancient people of Botra (Hunza people, Burusho/Brusho people), a hypothesis has been postulated through a number of modern quantum-mechanical, molecular-topological and bio analytical checks, and has also been confirmed by two proofs.
Methods: The proposed hypothesis underwent theoretical and logical analysis to confirm and/or reject it. The methodological scheme was: determining the optimal chemical formula, determination of the pharmaceutical molecular form and determination of the drug dose.
Results: A convenient, harmless, form of amygdalin derivative is available that has the same biological and chemical activity and could be used in conservative clinical oncology. The article also presents a theoretical comparative analysis of biochemical reactivity in in vivo and in vitro media, by which we also determine the recommended dosage for patient administration. A comparative analysis of the data, obtained in published clinical studies of amygdalin, is presented, summarizing a scheme of the anti-tumor activity of the proposed molecular form.
Conclusion: The hydrolyzed to amide / carboxylic acid cyano / nitrile glycosides are potential drugs. Their biological activity remains unchanged, but their toxicity is many times lower than unmodified native molecules. We claim that this study we have conducted on amygdalin / dhurrin-derived amide is the only study on this molecular form. Other substances in these groups with pronounced biological activity (including anti-tumor) are the hydrolyzed nitrile groups by Prunasin, Lucumin, Vicianin, Sambunigrin, Dhurrin, Taxiphyllin, Zierin, Preteacin, p-Glucosyloxymandelonitrile, Linamarin, Lotaustralin, Acaciapetalin, Triglochinin, Dejdaclin, Tetraphyllin A, Tetrallin B, Gynocardin and etc., to their amide/carboxylic acid.
Keywords: oncology, amygdalin, PM6, PM7, TD-DFT, pharmacological activity
Tsanov, V., Tsanov, H. (2020) Theoretical Analysis for the Safe Form and Dosage of Amygdalin Product,
Anti-Cancer Agents in Medicinal Chemistry, 20 (7), pp. 897÷908, Bentham Science Publisher
print ISSN: 1871-5206 | on-line ISSN: 1875-5992
DOI: 10.2174/1871520620666200313163801
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Proceeding from the particular to the general, the fine molecular structure and all possible biochemical reactions of amygdalin are examined. By itself, it is highly toxic to the physiologically active animal cell. The amygdalin has NO pronounced antitumor properties. In the first goal, he examines precisely the acceptable form for admission. It is concluded that the active anticancer molecular form is a stoichiometric mixture of the amide and carboxyl derivative of the nitrile glycoside.
For more up-to-date information please see this article in HTML 5 / 6MB single file size /.
The results of the analysis show that the studied molecular forms do NOT contradict conservative oncology. Their activity is significant and many times exceeds a number of approved products for treatment.
This anti-cancer agents could best be administered orally (p.o.). Their toxicity is many times less than that of most references accepted in clinical.
After analyzing the conclusions on the previous goals of the research, taking into account the presented clinical control, the data for the interpretable prognosis for susceptibility to active anti-cancer molecular forms of transcriptome cell lines inherent in tumors - for each anatomical system, good medical practices and the calculated data, we conclude that the treatment of oncological diseases should be carried out in four stages.
For more up-to-date information please see the latest version of the ATLAS on p.127 in HTML 5 / 31MB single file size /.
The bio constants of the human organism should not be accepted as a dogma, but simply used as benchmarks of the norm. Deviation from them should not necessarily be considered pathology. The human body adapts extremely well to the environment and strives to respond adequately to each stimulus.
Especially when performing chemotherapy on cancer patients, it is necessary to monitor the overall reference picture of the patient. It is good to avoid interpreting individual deviations from the physiologically healthy organism and to direct the treatment of cancer in the direction of "suppression" of individual symptoms.
Here the control forms that the clinician must comply with before and during chemotherapy are indicated. These are reference correlations that would directly affect the release of the active anticancer molecular form within the cancer cell.
VOLUME OF BLOOD: it is directly related to the fluid ratio, and secondarily to the water content in the body - hence the change in a number of physicochemical parameters.
When the total blood volume increases, it is important for the treating physician to rule out diagnoses:
HEMATOCRIT: In case of a decrease in the value of the hematocrit in the blood, it is obligatory for the attending physician to reject the diagnoses:
NATREMIA: Particular attention should be paid to cases of hyponatremia. Here the attending physician needs to comply with diagnoses such as:
KALEMIA: To some extent, hyperkalemia has a synergistic effect on the action of the studied dosage forms. It is good for the doctor to maintain higher blood potassium reference values. In cases where this is difficult, two circumstances must be taken into account:
CHLORAEMIA: Hypochloraemia alters the ionic and electrostatic activity of both amides and carboxylic acids - especially when they are in low concentrations in the blood. It is good to consider:
CALCEMIA: Hypercalcemia can suppress the spread of the drug form. Treatment should be resected and any comorbidities considered:
SIDERINEMIA: Hyposiderinemia could delay the detection of a more acidic environment around the cancer cell and from there slow down the action of the drug under study. The clinician should be aware that this is often accompanied by:
TOTAL IRON-BINDING CAPACITY: In case of increased content of total iron-binding capacity, it is necessary for the clinician to take into account the possible presence of:
CUPREMIA: Hypercupremia would significantly increase the need for a higher drug dose. She herself is also an indicator for:
ZINC CONTENT IN THE BLOOD:
The content of zinc in the blood determines its extremely complex role in cancer. Its compounds are both inhibitors and promoters. It can displace a number of metals from organometallic biologically active substances, but at the same time its coordination compounds in an in vivo medium are volatile.
We recommend a mandatory blood test for zinc in the blood before starting chemotherapy according to the studied experimental methodology. The following reference deviations must be taken into account:
For more up-to-date information please see the latest version of the ATLAS on p.135 in HTML 5 / 31MB single file size /.
The proposed methodological program for conservative treatment of oncological diseases does not contradict the good medical practices for chemotherapy. In order to improve the general condition of patients, chemoprevention and/or homeopathy could be applied, but not at the expense of a varied diet, incl. table salt, water, culinary acidifiers and fats. Alternative medicine should only be used to treat individual symptoms, not syndromes.
For more up-to-date information please see the latest version of the ATLAS on p.139 in HTML 5 / 31MB single file size /.
The Warburg effect and theory in themselves do not seriously contradict the theory (and its accompanying theorem) of the anti-tumor activity of amide and carboxyl derivatives of natural nitrile glycosides. There is only a certain distinction with the general definition of alkalization of the environment around the cancer cell itself. Scientific approaches and evidentiary methodologies are diametrically different and therefore it is not appropriate to compare them by each individual analyzed indicator.
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